15 Times Derrick Henry Couldn’t Be Stopped

When Derrick Henry gets going, defenders bounce off him like flies on a windshield. His size, speed, and refusal to go down turn ordinary plays into unforgettable runs. From regular season explosions to playoff heroics, he's made a habit of proving he's one of the most powerful running backs in football history.

Tricia Quitales
June 5, 2025
4 min read

15 Times Derrick Henry Couldn’t Be Stopped — © George Walker IV / Tennessean.com / USA TODAY NETWORK via Imagn Images

Derrick Henry has delivered some of the most dominant performances the NFL has ever seen from a running back. Known for breaking tackles and sprinting past entire defenses, his biggest games are filled with highlight moments. Whether it’s a 200-yard outburst or a stiff-arm that goes viral, Henry’s physical style makes him nearly impossible to stop. These 15 performances remind us just how unique and unstoppable he can be when he’s locked in.

1. 250 Yards vs. Texans (Week 17, 2020)

Henry ran wild with 250 yards and two touchdowns to close out the regular season. He became the eighth player in NFL history to rush for over 2,000 yards. The Texans had no answer for his nonstop power.

2. 99-Yard Touchdown vs. Jaguars (2018)

On Thursday Night Football, Henry delivered one of the most iconic runs ever. He stiff-armed multiple defenders on his way to a 99-yard score. That run instantly became a part of NFL history.

3. Playoff Win vs. Ravens (Divisional Round)

Henry ran for 195 yards and even threw a touchdown pass in a stunning road win. He dominated one of the best defenses in the league with ease. The Ravens simply couldn’t bring him down.

4. 212 Yards vs. Texans

In a high-scoring shootout, Henry broke free for a 94-yard touchdown in overtime. He finished the game with over 200 yards rushing and two scores. It was a perfect example of his game-breaking ability.

5. AFC Wild Card vs. Patriots

Henry carried the Titans into the next round with 182 yards and a touchdown. New England’s legendary defense had no way to slow him down. He controlled the clock and the game from start to finish.

6. 238 Yards vs. Jaguars

Not only did he have the 99-yard run, but Henry totaled four touchdowns and 238 yards that night. Jacksonville was overwhelmed and outmuscled. It was one of the best single-game efforts by any running back.

7. 178 Yards vs. Colts

Henry torched Indianapolis with three touchdowns in the first half alone. He broke through tackles and turned short runs into huge gains. The Colts looked exhausted trying to stop him.

8. 211 Yards vs. Texans

Once again, Henry feasted on the Texans in the final game of the season. He added three touchdowns to go with his yardage. The win helped Tennessee secure a top seed in the playoffs.

9. 143 Yards vs. Seahawks

Henry helped lead a comeback with three second-half touchdowns. He wore down the Seattle defense and exploded in the fourth quarter. Once he found his rhythm, no one could touch him.

10. 215 Yards vs. Jaguars (2020)

In yet another dominant performance against Jacksonville, Henry ran for over 200 yards with ease. His stiff-arms and power runs broke the game wide open. It seemed like he owned the Jaguars every time they met.

11. 182 Yards vs. Bills

He broke away for a 76-yard touchdown that reminded fans of his rare speed. The Bills’ defense couldn’t catch him once he turned the corner. Henry turned a tight game into a Titans win.

12. 147 Yards vs. Chiefs

Facing a playoff-caliber team, Henry added a passing touchdown to his rushing total. Kansas City had no way to contain his variety of skills. He kept their defense guessing all game long.

13. 170 Yards vs. Raiders (Week 3, 2022)

Henry dominated early with quick cuts and bruising runs up the middle. He found the end zone and helped the Titans grab an important win. The Raiders couldn’t match his strength.

14. 130 Yards vs. Packers (Week 11, 2022)

On a cold night at Lambeau Field, Henry powered through Green Bay’s front seven. He also threw a jump-pass touchdown, adding to his highlight reel. The defense never figured out how to contain him.

15. 153 Yards vs. Bengals (Week 8, 2023)

He hit the century mark before halftime and looked unstoppable with every carry. The Bengals’ defense collapsed under the pressure of his consistent gains. It was another game where Henry looked like a one-man wrecking crew.