10 Experiments Scientists Regret Doing
This listicle highlights 10 experiments that, in hindsight, are widely condemned for their moral violations, ranging from psychological manipulation to medical abuse.
- Daisy Montero
- 4 min read
Scientists have pushed for new discoveries over the years, and some of their choices caused real harm. These experiments led to strict rules on how research should be done. Their history shows that curiosity without care can hurt people in lasting ways.
1. 1. Milgram Obedience Experiment

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The Milgram Obedience Experiment showed how far people would follow instructions even when they believed they were hurting someone. Many volunteers felt intense stress because they thought they were delivering real electric shocks. The emotional pressure stayed with some participants long after the study ended. Milgram later expressed concerns about the impact of the experiment and how deeply it affected the people involved.
2. 2. Stanford Prison Experiment

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The Stanford Prison Experiment turned into chaos as soon as students stepped into their roles as guards and prisoners. Some guards became abusive, and several prisoners showed real signs of emotional distress. The study was shut down early due to unsafe conditions. It remains one of the strongest examples of how quickly people can misuse power when given authority.
3. 3. Tuskegee Syphilis Study

Centers for Disease Control and Prevention on Wikimedia Commons
The Tuskegee Syphilis Study followed Black men with untreated syphilis without telling them the truth. Many believed they were receiving help, but they were denied real medical care, even when treatment finally existed. Families suffered for years because of the choices made by the researchers. This study became a turning point that changed medical ethics in the United States.
4. 4. Project MKULTRA

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Project MKULTRA tested drugs and psychological methods on people who often did not know what was happening. Some subjects experienced fear, confusion, and long-lasting mental effects. The secrecy around the program added even more concern once the details became public. It is remembered as a major failure in respecting human rights during research.
5. 5. Willowbrook Hepatitis Study

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Doctors at Willowbrook State School exposed children to hepatitis so they could study how the disease spread. Many of the children did not understand what was being done to them, and families were pressured to agree. The conditions at the school were already poor, making the study even more troubling. It now stands as a clear example of research that ignored the safety of vulnerable people.
6. 6. Little Albert Experiment

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The Little Albert Experiment conditioned a young child to fear animals by pairing them with loud noises. The boy started showing fear not just toward the rat but also toward other furry objects. The researchers never attempted to reverse the fear they created. The study is often cited as an unethical approach to understanding human behavior.
7. 7. Holmesburg Prison Experiments

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At Holmesburg Prison, inmates were used in dermatology tests involving chemicals and drugs. Many prisoners were not fully informed about the risks or long-term effects. The tests caused fear and distrust among those who lived through them. The experiment is now viewed as a major violation of consent within medical research.
8. 8. Fe 59 Radiation Study

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The Fe 59 Radiation Study gave immigrant women radioactive iron to observe how their bodies absorbed it. Many of them did not understand the full purpose of the study or the dangers involved. Researchers prioritized data collection over patient safety. The study is now used as a lesson on the need for clear and honest consent in medical research.
9. 9. Psychic Driving

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Psychic Driving attempted to change patients by exposing them to repeated recorded messages. Some were also given strong medications and heavy electroshock sessions. The combination left many patients confused, distressed, and unable to return to normal routines. The doctor behind the work later faced major criticism for the harm the treatment caused.
10. 10. Project Artichoke

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Project Artichoke explored how drugs and hypnosis might influence a person’s behavior. Test subjects were sometimes pushed into highly stressful situations without proper consent. The program raised many questions about how far government research should go. It remains one of the most unsettling efforts from the early Cold War period.